News — dissolution vessels

The following article has been authored by John Heaney.  Coning of disintegrating dosage forms is fairly common when using Apparatus 2 (Paddles) to perform dissolution testing.  The reason for this is the spinning of the paddle causes a cone shaped zone to form directly beneath it where there is low hydrodynamic activity.  In other words, it’s a bit of a dead zone where the stirring has little effect, and the particles are allowed to settle. Depending on the formulation this coning can be problematic.  It can prevent drug from dissolving in the media due to a reduction in the effective...

The following article has been authored by John Heaney.   Variability is a fact of life in any manufacturing process.  That is the reason there are acceptance ranges and tolerances as well as QC departments to measure finished product ensuring that everything is acceptable.  The tools used by any QC department need to be as consistent as possible.  A pair of calipers that gives a slightly different reading each time when measuring an NIST standard block is not particularly valuable.  The same is true of dissolution testers, or more specifically vessels, that have high variability. High variability in the vessel...