News — paddle method
When to use a Sinker
Posted by Pam Bialiy on
The following article has been authored by John Heaney. Not all tablets, capsules, and gelcaps behave the same in dissolution media. In some cases, a dosage may be buoyant enough to move far more than normal when subjected to the turbulence caused by a paddle (Apparatus 2) if not float all the way to the surface. Either of these would be considered unacceptable if they were observed during a test. The case of a dosage form floating to the surface is obvious. It’s far out of position from the bottom of the dissolution vessel and is not subject to the...