News — Angled Disc

The following article has been authored by John Heaney.   Compared to dissolution Apparatus 1 (Baskets) and Apparatus 2 (Paddles), Dissolution Apparatus 3: Biodissolution (the reciprocating cylinder) is quite rare.  However, it has some key advantages over the more common baskets and paddles which can make it very useful for key applications. Apparatus 3 consists of a glass cylinder with a mesh screen at the bottom moving up and down in a specified distance and rate within a glass dissolution vessel.  The dosage form is held within the glass cylinder.  Vessels are typically arranged in rows allowing the glass cylinder...