News — Auto-Sampling

Sample filtration is a critical part of dissolution testing, yet there is no universal solution that works for every application. The most effective filtration approach depends on the specific analytical method, sample properties, and filter characteristics involved. Each method should be evaluated individually to ensure optimal performance and reliable results. For established methods that already specify a particular filter type or micron rating, there may be little flexibility in filter selection. However, when developing new methods, a successful filtration strategy should be based on three key considerations: 1. Analytical Method Requirements The analytical technique being used—typically UV spectroscopy or HPLC—plays...

The following article has been authored by John Heaney. Does the presence of a resident sampling probe affect the hydrodynamics of a dissolution vessel?  Yes, yes it does.  The more important questions are how strong is the change in the hydrodynamics and is it strong enough to affect testing? USP <1092>, an advisory chapter addresses this directly with:  Sampling probes may or may not remain in the vessel throughout the entire run. Sampling probes or fiber-optic probes can disturb the hydrodynamics of the vessel; therefore, adequate validation should be performed to ensure that the probes are not causing a significant...