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Thoughts on Small Volume Dissolution
Posted by Pam Bialiy on
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The following article has been authored by John Heaney. Compared to the rest of dissolution testing, small volume dissolution is in a bit of a strange position within the industry. The bulk of dissolution testing is set around well-defined apparatus with specific dimensional tolerances and a 1 L glass vessel with a hemispherical bottom.  Small volume dissolution can vary widely, the main commonality being that the maximum capacity of the vessels is significantly smaller than 1 L. The first question one may ask is why do small volume dissolution at all? As pharmaceutical technology improves, with better chemistry and things...