News — immersion cell

The following article has been authored by John Heaney.   While Immersion/Enhancer Cells and Vertical Diffusion/Franz cells are both used to test semi-solid dosage forms; the capabilities of each apparatus are important to understand before deciding which is best for your lab.  Testing of semi-solid dosage forms is broadly categorized into In-Vitro Permeation Testing (IVPT), and In-Vitro Release Testing (IVRT).  The types of testing serve very different purposes and have different requirements. IVPT is primarily used to simulate how a semi-solid dosage form will behave in-vivo or when a patient makes use of it.  This typically uses bio-relevant media and has...

The following article has been authored by John Heaney. Compared to the rest of dissolution testing, small volume dissolution is in a bit of a strange position within the industry.  The bulk of dissolution testing is set around well-defined apparatus with specific dimensional tolerances and a 1 L glass vessel with a hemispherical bottom.   Small volume dissolution can vary widely, the main commonality being that the maximum capacity of the vessels is significantly smaller than 1 L. The first question one may ask is why do small volume dissolution at all?  As pharmaceutical technology improves, with better chemistry and things...