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News — Small Volume Dissolution

Thoughts on Small Volume Dissolution

Posted by Pam Bialiy on

Thoughts on Small Volume Dissolution

The following article has been authored by John Heaney. Compared to the rest of dissolution testing, small volume dissolution is in a bit of a strange position within the industry.  The bulk of dissolution testing is set around well-defined apparatus with specific dimensional tolerances and a 1 L glass vessel with a hemispherical bottom.   Small volume dissolution can vary widely, the main commonality being that the maximum capacity of the vessels is significantly smaller than 1 L. The first question one may ask is why do small volume dissolution at all?  As pharmaceutical technology improves, with better chemistry and things...

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