News — low solubility

The following article has been authored by John Heaney.   Compared to dissolution Apparatus 1 (Baskets) and Apparatus 2 (Paddles), Dissolution Apparatus 3: Biodissolution (the reciprocating cylinder) is quite rare.  However, it has some key advantages over the more common baskets and paddles which can make it very useful for key applications. Apparatus 3 consists of a glass cylinder with a mesh screen at the bottom moving up and down in a specified distance and rate within a glass dissolution vessel.  The dosage form is held within the glass cylinder.  Vessels are typically arranged in rows allowing the glass cylinder...

The following article has been authored by John Heaney.  Like the reciprocating cylinder (Apparatus 3), the flow-through diffusion cell (Apparatus 4) is quite rare compared to baskets (Apparatus 1) and paddles (Apparatus 2).  But there are some distinct advantages to flow-through cell that can make it a boon to certain formulations. The design of the flow-through cell consists of a cell with specific dimensions with the dissolution media fed through it by a pump.  The dissolution media is typically stored in a reservoir.  The media can be recirculated which is referred to as a closed-system; or constantly dispensed and collected...