News — deaeration

  The following article has been authored by John Heaney. Intrinsic dissolution is a specific niche of dissolution testing often reserved for early R&D.  The purpose is to provide scientists with an idea of the solubility of the API they’re studying.  This data can be invaluable as it will help determine the excipients required to develop an oral dosage form. There are 2 types of methods for this.  The first is a Rotating Disk (often called the Wood’s Apparatus) and the second is Stationary Disk.  In both cases a pellet of the pure drug is pressed into a drug compact...

The following article has been authored by John Heaney.   Deaeration, or degassing, of dissolution media is not required for every dissolution method, but when it is required it is critically important.  The USP Prednisone PVT requires deaeration of the dissolution media and the tablet is formulated to show whether or not the deaeration method is adequate.  Deaeration tends to have a larger impact on dissolution results as compared to other factors regarding the dissolution test.  How this shows itself can change depending both on the apparatus, and the dosage being tested. How to deaerate is largely up to the...